Question 1

How do I use Semaglutide for weight management? (0.25mg, 0.5mg, 1mg)

Accepted Answer

Semaglutide follows a gradual dose escalation: start at 0.25mg weekly for 4 weeks, increase to 0.5mg for 4 weeks, then 1mg maintenance dose. Inject subcutaneously once weekly on the same day. Rotate injection sites between abdomen, thigh, and upper arm.

Question 2

What is the Tirzepatide dosing schedule? (2.5mg to 30mg)

Accepted Answer

Tirzepatide dosing starts at 2.5mg weekly for 4 weeks, then increases by 2.5mg every 4 weeks. Standard doses range from 5mg to 15mg, with advanced doses of 20mg and 30mg available for patients who need them under medical supervision.

Question 3

How should I use NAD+ injections? (100mg, 200mg, 500mg)

Accepted Answer

NAD+ injections are available in 100mg (maintenance), 200mg (standard therapeutic), and 500mg (intensive support) formulations. Subcutaneous injections are typically administered 2-3 times per week. IV infusions of 500mg may be given 1-2 times monthly for more intensive therapy.

Question 4

What is the Retatrutide dosing protocol? (20mg vial)

Accepted Answer

Retatrutide dosing starts at 1mg weekly and gradually increases to target doses of 8mg or 12mg weekly over several months. The 20mg multi-dose vial allows healthcare providers to administer multiple doses, making it cost-effective for clinic use.

Question 5

What is the starting dose for Semaglutide?

Accepted Answer

The starting dose for Semaglutide is 0.25mg once weekly for the first 4 weeks. This low starting dose allows your body to adjust to the medication and minimizes gastrointestinal side effects like nausea. After 4 weeks, most patients increase to 0.5mg weekly, then to the maintenance dose of 1mg weekly after another 4 weeks.

Question 6

How often should I inject Tirzepatide?

Accepted Answer

Tirzepatide is injected once weekly, on the same day each week. You can choose any day that works best for your schedule. If you miss your regular injection day, take it as soon as you remember if within 4 days. If more than 4 days have passed, skip the missed dose and continue with your next scheduled dose.

Question 7

Can I take Semaglutide twice a week instead of once?

Accepted Answer

No, Semaglutide should only be taken once weekly as prescribed. Taking it more frequently does not improve results and may increase side effects significantly. The medication is designed to work over a 7-day period.

Question 8

What is the maximum dose of Tirzepatide?

Accepted Answer

The maximum FDA-approved dose of Tirzepatide is 15mg weekly for the branded medication. However, in clinical settings, some patients use higher doses (20mg or 30mg) under close medical supervision.

Question 9

How should I store Semaglutide before and after opening?

Accepted Answer

Before first use, store Semaglutide in the refrigerator at 36-46 deg F (2-8 deg C). Do not freeze. After first use, you can keep it refrigerated or at room temperature (up to 86 deg F/30 deg C) for up to 56 days. Protect from light and keep the cap on when not in use.

Question 10

Can I store Tirzepatide at room temperature?

Accepted Answer

Unopened Tirzepatide should be stored in the refrigerator (36-46 deg F / 2-8 deg C). Once in use, it can be stored at room temperature (up to 86 deg F/30 deg C) for up to 21 days. Never freeze Tirzepatide.

Question 11

What happens if Semaglutide gets warm?

Accepted Answer

Brief exposure to temperatures slightly above 86 deg F (30 deg C) may not immediately damage Semaglutide, but prolonged exposure can affect its potency. If your medication has been left in a hot car or exposed to high temperatures for extended periods, it is safest to discard it.

Question 12

How long does reconstituted NAD+ last?

Accepted Answer

Reconstituted NAD+ should be stored in the refrigerator and used within 28 days. Keep it protected from light and never freeze it. Before each use, check that the solution is clear and free of particles.

Question 13

Can I travel with Semaglutide on an airplane?

Accepted Answer

Yes, you can travel with Semaglutide by airplane. Keep it in your carry-on bag (not checked luggage) to avoid extreme temperature exposure. Use an insulated cooling pouch or travel case to maintain proper temperature.

Question 14

How do I reconstitute Tirzepatide powder?

Accepted Answer

To reconstitute Tirzepatide powder: clean the vial top with an alcohol swab, draw the specified amount of bacteriostatic water into a syringe, inject slowly into the vial aiming at the glass wall, gently swirl until fully dissolved, store in refrigerator and use within 28 days.

Question 15

What are the common side effects of Semaglutide in the first week?

Accepted Answer

In the first week of Semaglutide, common side effects include mild nausea (most common, affects ~20-40% of users), decreased appetite, slight fatigue, and occasional headache. These effects are usually mild and temporary.

Question 16

How do I manage Tirzepatide nausea?

Accepted Answer

To manage Tirzepatide nausea: eat smaller, more frequent meals, avoid high-fat, greasy, or spicy foods, stay well-hydrated, try ginger tea, do not lie down immediately after eating, and take your injection in the evening before bed. Nausea typically improves after 2-4 weeks.

Question 17

Does Semaglutide cause hair loss?

Accepted Answer

Some patients report hair loss (telogen effluvium) while using Semaglutide, though it is not a common side effect. This is typically related to rapid weight loss rather than the medication itself. Ensure adequate protein intake and consider biotin supplementation.

Question 18

What causes sulfur burps on Tirzepatide?

Accepted Answer

Sulfur burps on Tirzepatide are caused by delayed gastric emptying, which allows food to sit longer in the stomach and ferment. This is more common with higher doses or after eating high-protein or high-sulfur foods.

Question 19

Can GLP-1 medications cause constipation?

Accepted Answer

Yes, constipation is a common side effect of GLP-1 medications, affecting about 10-15% of users. This occurs because the medication slows down your entire digestive system. Increase fiber intake gradually, drink plenty of water, and exercise regularly.

Question 20

Does NAD+ injection have side effects?

Accepted Answer

NAD+ injection side effects are generally mild and may include temporary flushing or warmth at injection site, mild nausea, slight headache, and occasional fatigue. Starting with lower doses and increasing gradually minimizes side effects.

Question 21

Semaglutide vs Tirzepatide: Which is better for weight loss?

Accepted Answer

Clinical trials show Tirzepatide may produce greater weight loss than Semaglutide. Tirzepatide showed up to 22.5% body weight reduction at the highest dose, compared to about 15% with Semaglutide. However, the best choice depends on individual factors.

Question 22

What is the difference between Ozempic and Semaglutide?

Accepted Answer

Ozempic IS Semaglutide - it is a brand name. Ozempic is specifically approved for type 2 diabetes, while Wegovy (also Semaglutide) is approved for weight management. Both contain the same active ingredient.

Question 23

Is Retatrutide better than Tirzepatide?

Accepted Answer

Retatrutide has shown higher weight loss in clinical trials (up to 24% body weight reduction) compared to Tirzepatide (up to 22.5%). However, Retatrutide is still in clinical trials and not yet FDA-approved, while Tirzepatide is approved and widely available.

Question 24

NAD+ vs NMN: Which supplement is better?

Accepted Answer

NAD+ and NMN work differently: NAD+ is the active molecule your cells need, while NMN is a precursor that your body converts to NAD+. Injectable NAD+ provides direct supplementation with high bioavailability. For daily maintenance, NMN supplements may be more convenient.

Question 25

Compounded Semaglutide vs brand name: Is there a difference?

Accepted Answer

Compounded Semaglutide contains the same active molecule as brand-name products (Ozempic, Wegovy). The difference is in manufacturing - compounded versions are made by compounding pharmacies under FDA oversight. Benefits include more flexible dosing options and often lower cost.

Question 26

Should I switch from Semaglutide to Tirzepatide?

Accepted Answer

Consider switching if you have plateaued on Semaglutide, are not achieving desired results, or experience persistent side effects. Tirzepatide's dual mechanism may help overcome plateaus. The two medications should not be used together.

Question 27

What foods should I avoid while taking Semaglutide?

Accepted Answer

While on Semaglutide, avoid or minimize high-fat greasy foods, large portions, sugary foods and drinks, alcohol, spicy foods, and carbonated beverages. Focus on lean proteins, vegetables, and small portions.

Question 28

What should I eat on Tirzepatide for best results?

Accepted Answer

Focus on lean proteins (chicken, fish, eggs, tofu) aiming for 20-30g per meal, non-starchy vegetables, complex carbs in moderation, healthy fats, and plenty of water. Prioritize protein to preserve muscle mass.

Question 29

Can I drink alcohol while taking GLP-1 medications?

Accepted Answer

Alcohol should be limited while taking GLP-1 medications. It can worsen nausea and GI side effects, and slowed gastric emptying makes alcohol absorption unpredictable. If you do drink, limit to 1-2 drinks occasionally.

Question 30

How much protein do I need on Semaglutide?

Accepted Answer

On Semaglutide, aim for 0.7-1g of protein per pound of ideal body weight daily (about 60-100g for most people). Spread protein throughout the day (20-30g per meal). Good sources include chicken, fish, eggs, Greek yogurt, and legumes.

Question 31

How much weight can I expect to lose on Semaglutide?

Accepted Answer

Clinical trials show average weight loss of 15-17% of body weight over 68 weeks with Semaglutide 2.4mg. Individual results vary widely. Most people see noticeable results within 8-12 weeks.

Question 32

When will I start seeing results on Tirzepatide?

Accepted Answer

Most people begin noticing results on Tirzepatide within 4-8 weeks. You may notice decreased appetite within the first week, reduced cravings by week 2-3, measurable weight loss by week 4-8, and significant changes by week 12+.

Question 33

Will I regain weight if I stop Semaglutide?

Accepted Answer

Studies show most people regain weight after stopping GLP-1 medications - about 2/3 of lost weight may return within a year. Options include long-term use, transitioning to a lower maintenance dose, or combining with intensive lifestyle modification.

Question 34

How long do NAD+ benefits last?

Accepted Answer

After IV infusion, acute effects (energy, clarity) may last 3-7 days. Regular subcutaneous injections (2-3x weekly) maintain more stable levels. Cellular benefits accumulate over weeks to months of consistent use.

Question 35

What results can I expect from NAD+ therapy?

Accepted Answer

Common NAD+ therapy results include improved energy levels, better mental clarity and focus, enhanced exercise recovery, improved sleep quality, better skin appearance over time, and general sense of well-being. Results are dose and frequency dependent.

Question 36

What is NAD+ and why is it important?

Accepted Answer

NAD+ (Nicotinamide Adenine Dinucleotide) is a crucial coenzyme found in every cell of your body. It plays a vital role in energy metabolism, DNA repair, and cellular health. NAD+ levels naturally decline with age.

Question 37

How does NAD+ therapy work?

Accepted Answer

NAD+ therapy works by supplementing your body's natural NAD+ levels through various delivery methods including oral supplements, sublingual administration, or injection therapy. Once absorbed, NAD+ supports mitochondrial function, helps repair DNA, and activates sirtuins.

Question 38

Who should consider NAD+ supplementation?

Accepted Answer

NAD+ supplementation may be considered by individuals interested in supporting cellular health, energy levels, and healthy aging. It may be relevant for those experiencing age-related fatigue, cognitive changes, recovery from illness, or athletic performance optimization.

Question 39

What is the best NAD+ dosage for anti-aging?

Accepted Answer

For anti-aging purposes, typical NAD+ dosing is 100-200mg subcutaneously 2-3x per week for maintenance, or 500mg IV infusions 1-2x monthly for more intensive therapy. The best dose depends on your age, health status, and goals.

Question 40

Can NAD+ help with energy and fatigue?

Accepted Answer

Yes, NAD+ is directly involved in cellular energy production through its role in mitochondrial function. Many people report improved energy levels after NAD+ therapy, sometimes within days of starting.

Question 41

What is the difference between Semaglutide, Tirzepatide, and Retatrutide?

Accepted Answer

Semaglutide is a GLP-1 receptor agonist. Tirzepatide is a dual GIP/GLP-1 receptor agonist. Retatrutide is a triple agonist targeting GIP, GLP-1, and glucagon receptors, representing the most advanced approach with the highest weight loss efficacy in clinical trials (up to 24%).

Question 42

How does GLP-1 medication work for weight loss?

Accepted Answer

GLP-1 medications activate GLP-1 receptors in the brain's appetite centers reducing hunger, slow gastric emptying making you feel full longer, improve insulin sensitivity, and may reduce reward-based eating.

Question 43

Are GLP-1 medications FDA approved?

Accepted Answer

Yes, several GLP-1 medications are FDA approved. Semaglutide as Ozempic (diabetes) and Wegovy (weight loss). Tirzepatide as Mounjaro (diabetes) and Zepbound (weight loss). Retatrutide is still in clinical trials.

Question 44

Can GLP-1 medications help with type 2 diabetes?

Accepted Answer

Yes, GLP-1 medications were originally developed for type 2 diabetes and remain highly effective for blood sugar control. They improve insulin secretion, reduce glucagon release, and help with weight loss.

Question 45

What happens if I miss a dose?

Accepted Answer

For weekly GLP-1 medications: if missed by less than 5 days, take the dose as soon as you remember. If missed by 5 or more days, skip the missed dose and take your next dose on the regularly scheduled day. Never double up doses.

Question 46

How should I store these medications?

Accepted Answer

Semaglutide/Tirzepatide: Refrigerate at 36-46 deg F (2-8 deg C) before first use. After first use, can be stored at room temperature for up to 21-28 days. NAD+: Store in refrigerator, protect from light, do not freeze.

Question 47

Where is the best injection site for Semaglutide?

Accepted Answer

The best injection sites for Semaglutide are the abdomen (most popular, avoid 2 inches around navel), front of thighs, and back of upper arm. Rotate injection sites to prevent lipodystrophy.

Question 48

How do I inject subcutaneously at home?

Accepted Answer

For subcutaneous injection: wash hands, clean injection site with alcohol, pinch a fold of skin, insert needle at 45-90 degree angle, inject medication slowly, hold for 5-10 seconds, remove needle and release skin. Rotate between abdomen, thighs, and arms.

Question 49

Do I need a prescription for GLP-1 medications?

Accepted Answer

Yes, GLP-1 medications like Semaglutide and Tirzepatide are prescription medications and require a prescription from a licensed healthcare provider.

Question 50

Can I exercise while taking GLP-1 medications?

Accepted Answer

Yes, exercise is encouraged while taking GLP-1 medications and can enhance your results. Focus on resistance training 2-3x weekly and moderate cardio. Reduced appetite means you may need to time meals around workouts.

Question 51

Are GLP-1 medications safe for weight management?

Accepted Answer

GLP-1 medications like Semaglutide and Tirzepatide have been extensively studied and approved by the FDA for weight management when used under medical supervision. Common side effects typically improve with proper dose titration.

Question 52

Who should not take GLP-1 medications?

Accepted Answer

GLP-1 medications may not be appropriate for people with personal/family history of medullary thyroid cancer or MEN2 syndrome, history of pancreatitis, pregnant or breastfeeding women, people with severe kidney disease, or those with gastroparesis.

Question 53

Can I take Semaglutide while pregnant?

Accepted Answer

No, Semaglutide should not be taken during pregnancy. Stop Semaglutide at least 2 months before planning pregnancy. If you become pregnant while taking it, stop immediately and contact your healthcare provider.

Question 54

Is this medical advice?

Accepted Answer

No. All content provided by Prost Biotech is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a licensed healthcare provider.

Question 55

What should I do if I experience severe side effects?

Accepted Answer

If you experience severe side effects, stop the medication and seek medical attention. Urgent symptoms include severe abdominal pain, persistent vomiting, signs of allergic reaction, vision changes, rapid heartbeat, or severe dizziness.

Question 56

What are the signs of pancreatitis from GLP-1 medications?

Accepted Answer

Pancreatitis signs include severe persistent abdominal pain (often upper abdomen radiating to back), pain that worsens after eating, nausea and vomiting that does not stop, fever, and rapid heartbeat. Stop the medication and seek emergency care immediately.

Question 57

What is the thyroid cancer warning for GLP-1 medications?

Accepted Answer

GLP-1 medications carry a black box warning about thyroid C-cell tumors based on animal studies. Do NOT use if you have personal/family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia type 2 (MEN2).

Question 58

What medications interact with Semaglutide or Tirzepatide?

Accepted Answer

GLP-1 medications may interact with insulin and sulfonylureas (increased hypoglycemia risk), oral medications (delayed absorption), blood thinners, oral contraceptives, and levothyroxine. Always inform your healthcare provider of all medications you take.

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