Dosing Guide
Tirzepatide Dosing Protocol
Complete Tirzepatide dosing guide from 2.5mg to 15mg. Mounjaro/Zepbound injection schedule, dose escalation protocol, and administration instructions for weight loss.
Dosing Schedule
| Phase | Dose | Duration | Purpose |
|---|---|---|---|
| Starting | 2.5mg | Week 1-4 | Initiation dose only |
| Escalation 1 | 5mg | Week 5-8 | First therapeutic dose |
| Escalation 2 | 7.5mg | Week 9-12 | Intermediate dose |
| Escalation 3 | 10mg | Week 13-16 | Standard therapeutic dose |
| Advanced | 12.5mg | Week 17-20 | Enhanced effect dose |
| Maximum | 15mg | Week 21+ | Full therapeutic dose |
Administration Instructions
- Inject subcutaneously once weekly
- Can be administered any time of day, with or without food
- Injection sites: abdomen, thigh, or upper arm
- Rotate injection sites to prevent tissue damage
- Store refrigerated before first use; can be at room temperature for up to 21 days after
- Do not freeze or use if previously frozen
Key Benefits
- Dual GIP/GLP-1 mechanism for enhanced efficacy
- Up to 22.5% weight loss in clinical trials (SURMOUNT-1)
- Superior A1C reduction compared to single agonists
- Flexible dosing range for personalized treatment
- Improved cardiovascular risk factors
- Reduction in waist circumference and body fat percentage
Safety Notes & Precautions
- Contraindicated in patients with personal or family history of MTC or MEN 2
- Start at 2.5mg and do not skip dose escalation steps
- Gastrointestinal side effects are most common during dose escalation
- Monitor for signs of acute pancreatitis
- May affect absorption of oral medications due to delayed gastric emptying
Medical Disclaimer: This dosing guide is for educational purposes only. Individual dosing should be determined by a licensed healthcare provider based on your specific health conditions, medical history, and treatment goals. Never adjust your dosing without consulting your healthcare provider. Side effects should be reported immediately, and dose escalation should only occur under medical supervision.